I think this is a fascinating article as to some extent it suggests that an era that marked the formation of nations states in Europe which mirrored the first industrial revolution and the need for capital to accumulate and aggregate and for geopolitical success to be based on size and not locality, is breaking down. 

As a result of the digital revolution and a reaction to globalisation, local and not national needs are once more to the fore. Does Catalonia need Spain either economically or politically? Does London or Manchester need the rest of the UK? London and Manchester were very strong pro-remain and pro-immigration areas imbued by social liberalism and economic dynamism very different places from say East Kent or Lincolnshire. This feels both an economic and social issue throughout Europe that will not dissipate.  The notion of the all powerful global state has perhaps hit the rocks - not able to deliver agile enough economic growth or meaningful social inclusion.